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Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient nonclassic
adrenal hyperplasia in hyperandrogenic women with adrenal androgen
excess.



Title
Prevalence of 3beta-hydroxysteroid dehydrogenase-deficient
nonclassic adrenal
hyperplasia in hyperandrogenic women with adrenal androgen excess.
Author
Moran C; Potter HD; Reyna R; Boots LR; Azziz R
Address
Department of Obstetrics, The University of Alabama at Birmingham,
USA.
Source
Am J Obstet Gynecol, 181(3):596-600 1999 Sep
Abstract
OBJECTIVE: We sought to determine the prevalence of
3beta-hydroxysteroid
dehydrogenase-deficient nonclassic adrenal hyperplasia among adult
hyperandrogenic
women with dehydroepiandrosterone sulfate excess. STUDY DESIGN:
Thirty consecutive
hyperandrogenic women with hirsutism, oligomenorrhea, or both and
dehydroepiandrosterone sulfate levels of >8.5 micromol/L and 24
control subjects were
studied. Basal sex hormone binding globulin, total and free
testosterone,
dehydroepiandrosterone sulfate, 17-hydroxyprogesterone, and basal
and 60-minute
corticotropin-stimulated 17-hydroxypregnenolone and
dehydroepiandrosterone were
measured, and the increment (change from basal to 60-minute value)
was calculated.
RESULTS: Twenty-six (87%) and 25 (83%) of the 30 hyperandrogenic
patients studied
had 60-minute dehydroepiandrosterone and change in 0- to 60-minute
dehydroepiandrosterone levels greater than the mean + 2 SD of
control subjects,
respectively. Six (20%) and 6 (20%) of the 30 hyperandrogenic
patients had 60-minute
17-hydroxypregnenolone and 0- to 60-minute change in
17-hydroxypregnenolone levels
greater than the mean + 2 SD of control subjects, respectively.
However, none of the
subjects had either 60-minute 17-hydroxypregnenolone levels or
60-minute
dehydroepiandrosterone levels or both associated with the diagnosis
of genetically proved
3beta-hydroxysteroid dehydrogenase deficiency (>5-fold of the
control mean value).
CONCLUSION: 3beta-Hydroxysteroid dehydrogenase-deficient nonclassic
adrenal
hyperplasia is rare even among adult hyperandrogenic patients with
adrenal androgen
excess.
Language
Eng
Unique Identifier
99417444