One of several factors for the AMG-706 PHASE I clinical trial
locations may have been the existing locations of previous trials for
GIST patients for the Pfizer drug SU11248. Some Patients who were
still progressing on SU11248 were offered entry into some early AMG-
706 trials as a next step. This could have influenced, for example,
the selection of MD Anderson in Houston, TX, or the AMG-706 Phase I
trial location at Premier Oncology in Santa Monica, CA, just the
other side of L.A. from City of Hope Cancer Center in Duarte, CA.
Both areas are near where GIST patients who had failed Gleevec were
trying SU11248 (aka Sugen), and also failing on that. (Speculation
on my part, only.)

In any event, Amgen asks that patients telephone the Amgen Call
Center (1-866-572-6436) for a pre-screen, to be advised and directed
to the closest available AMG-706 clinical trial center. Available
sites might conceivably expand if the drug's safety/efficacy profiles
still look good into PHASE II and III clinical trials, where larger
numbers of participants would be recruited to make up a large enough
statistical data pool.

Charles

--- In AMG706@yahoogroups.com, Iahmed9@a... wrote:
> Why there are no clinical trials scheduled in the San Francisco Bay
Area
> either at Stanford or at UCSF.
>
> I thought AMGEN was located in South San francisco. Wouldn't it
make sense
> to have a trial location for the Bay Area lms and GIST patients?
>
> Iqbal