Will be done.

Let me know when.

G...

--- In ALS_India@yahoogroups.com, Gopala Krishna Gokeda <gokeda@...> wrote:
>
> Hi Gaurav,
>  
> Thanks for your mail. These injections will be coming from Philippines to
Delhi. A friend's friend is doing this favour to me. If you can send these to
Visakhapatnam, that'll be great. I shall give you more details soon.
>  
> Thanks very much
>  
> Gopal
>  
>
> --- On Tue, 3/10/09, gauravjain_80 <gauravjain_80@...> wrote:
>
>
> From: gauravjain_80 <gauravjain_80@...>
> Subject: [ALS_India] Re: WHY THE NEW GENE FINDINGS ARE A CALL TO ACTION - A
PACKARD PERSPECTIVE
> To: ALS_India@yahoogroups.com
> Date: Tuesday, March 10, 2009, 3:17 PM
>
>
>
>
>
>
> Dear Gopal,
> My co bro is travelling to US soon (within 15 days or so).
> If you can get the injections couriered to him, he can bring it back to India
and I can forward it to your folks.
>
> Let me know.
>
> Can be done...
>
> G...
> --- In ALS_India@yahoogrou ps.com, "gauravjain_ 80" <gauravjain_ 80@> wrote:
> >
> > Dear Gopal,
> >
> > glad 2 hear that ur mum is doing fine...
> > I was able 2 get Carnitine tabs but nt the injections.
> > Sorry about that.
> > Let me know if you still need the tabs...
> >
> > Tc and keep in touch...
> >
> > G..
> >
> > --- In ALS_India@yahoogrou ps.com, Gopala Krishna Gokeda <gokeda@> wrote:
> > >
> > > Hi Lalit,
> > >
> > > Please feel free to call me. My phone number is 705-293-0323 and
705-888-1246. My mother is doing very well. I am having hard time getting the
carnitine injections to India. I am still working on them.
> > >
> > > Gopal
> > >
> > >
> > >
> > >
> > >
> > > --- On Fri, 3/6/09, Lalit Kumar <lalitgupta907@ > wrote:
> > >
> > > From: Lalit Kumar <lalitgupta907@ >
> > > Subject: Re: [ALS_India] WHY THE NEW GENE FINDINGS ARE A CALL TO ACTION -
A PACKARD PERSPECTIVE
> > > To: ALS_India@yahoogrou ps.com
> > > Date: Friday, March 6, 2009, 10:24 PM
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > >
> > > hello gaurav bhaiya
> > > Do you know any thing about gopal's mother...one thing i want to know once
gopal told me about his neighbour in canada that the person was able to cure his
wife from MND by giving injection of l-carnitine. ..Do u know any thing about
this context????? ??Also do u have any phone no 4 contacting him... want to know
about that lady who was able to cure 4m this prob.....can u do any help regardig
this....If gopal got this mail kindly respond me..
> > >
> > >  
> > > thanx
> > >  
> > > lalit
> > >
> > >  
> > > On 3/5/09, gauravjain_80 <gauravjain_ 80@ yahoo.com> wrote:
> > >
> > >
> > >
> > >
> > >
> > > WHY THE NEW GENE FINDINGS ARE A CALL TO ACTION - A PACKARD PERSPECTIVE
> > > http://www.alscente r.org/news/ briefs/090304. cfm
> > >
> > >
> > > In 2003, when New England ALS scientists announced they'd discovered
> > > another form of familial ALS - the sixth one, and an adult form that
> > > seems to strike harder in the lower extremities and have a somewhat
> > >
> > > faster course - the hope was that the gene for it would soon surface.
> > >
> > > High excitement in the ALS research community always accompanies
> > > finding a new gene: Perhaps this one holds clues to reveal what triggers
> > >
> > > motor neuron death; perhaps this one will spark a really effective
> > > therapy.
> > >
> > > Last week, after a six-year search, the gene was announced by seasoned
> > > collaborators at the University of Massachusetts and Massachusetts
> > >
> > > General Hospital. Another research team at King's College in London
> > > backed up the finding. Found where they'd suspected it, on chromosome
> > > 16, the mutated FUS gene (for "fused in sarcoma") is responsible for
> > >
> > > perhaps 5 percent of familial ALS. And pinpointing it, after a long,
> > > thorough search, would be news enough.
> > >
> > > But this discovery appears to go beyond the usual. Packard scientists
> > > warmly welcome the appearance of m(for mutated) FUS for a key reason: It
> > >
> > > lends clout to a theory about a major destructive process in ALS that's
> > > been gathering evidence at the Packard Center and elsewhere more than a
> > > decade.
> > >
> > > "The fascinating thing about having the FUS gene linked to ALS," says
> > >
> > > Packard Scientific Director Piera Pasinelli, "is that it's yet another
> > > gene that plays a part in RNA processing."
> > >
> > > And having successful functioning of that molecule is crucial for cells
> > > to work normally. By way of background: RNA - specifically the messenger
> > >
> > > RNA molecule - carries DNA's blueprint for assembling proteins into the
> > > cell cytoplasm where their actual assembly occurs. Yet getting RNA to
> > > reflect DNA's "message" accurately, modifying it for efficiency and then
> > >
> > > transporting it from the cell nucleus to the cytoplasm is an involved,
> > > multi-step process. And it's a one that can go awry.
> > >
> > > In 1998, Packard scientists first published the find that some 65
> > > percent ALS patients harbor abnormal messenger RNA molecules,
> > >
> > > specifically in the injured parts of their central nervous systems. But
> > > no one has known the cause of that or what, if any, part it plays in
> > > ALS's downhill course.
> > >
> > > More evidence: Not long ago, Packard researchers helped discover the
> > >
> > > familial ALS4 gene, one for an abnormal form of a protein called
> > > senataxin. Like FUS, the senataxin gene also has an RNA role, overseeing
> > > proper production of messenger RNA from its DNA blueprint.
> > >
> > > And last year, the King's College group showed mutations in yet another
> > >
> > > gene - one called TDP-43 - that appears both in patients with a variety
> > > of different familial ALS types and, amazingly, in sporadic ALS patients
> > > as well. Healthy people lack these mutations. (Last week, Packard
> > > scientist Wim Robberecht and his European team added to that,
> > >
> > > discovering a new variation of the TDP-gene in familial ALS patients.)
> > > *
> > >
> > > Among TDP-43's list of accomplishments? RNA processing.
> > >
> > > All this suggests that flawed RNA metabolism, then, may join ALS's
> > >
> > > seven "ugly stepsisters, " as another of the biological pathways to go
> > > wrong in ALS. (In scientific terms, the seven stepsisters are: oxidative
> > > damage, misfolded protein aggregates, dysfunctional mitochondria,
> > >
> > > defects in motor neuron transport, growth factor deficiency, pathology
> > > of glial cells, glutamate excitotoxicity. )
> > >
> > > What has Packard scientists most engaged, however, is where the flawed
> > > RNA metabolism could lead. It's interesting, for example, that both
> > >
> > > patients with ALS from mTDP-43 and those with ALS from mFUS appear to
> > > show clumps of misfolded proteins - protein aggregates - in central
> > > nervous system cells, early in the disease. "This suggests that these
> > >
> > > aggregates are key agents, that they participate early in the genesis of
> > > ALS," says Packard scientist Phil Wong, who has just made a mouse model
> > > of ALS using a mutant TDP-43 gene.
> > >
> > > So an important next step, both for understanding and for therapy, Wong
> > >
> > > says, is to "see whether these aggregates are indeed critical players or
> > > if, instead, they're just `tombstones' that mark dying motor neurons."
> > > His mouse model should help answer that question.
> > >
> > >
> > > In this, the new "stepsister" may be the most useful. Because it shows
> > > up in both familial and sporadic patients, some researchers are even
> > > speculating that RNA gone awry may be the missing overarching principle
> > >
> > > that tells how the stepsisters are related. In other words, some are
> > > hoping it may be the key process that causes ALS.
> > >
> > > "The new discoveries, we believe, point strongly to flawed RNA
> > > metabolism as a key disease process to imitate in animal models for
> > >
> > > ALS," says Rothstein.
> > >
> > > "It's these tools - the gene-primed model mice and fish and fruit flies
> > > that Packard scientists offer the world's research community - that will
> > > enable us to understand ALS. Ultimately, they'll become the agents we'll
> > >
> > > all use to find effective therapies."
> > >
> > > *Robberecht is already busy making a zebrafish model of ALS using
> > > mutant TDP-43. His Packard colleague J. Paul Taylor, has begun testing a
> > > new TDP-43 fruit fly model.
> > >
> > >
> > > ____________ _________ _________ _____
> > >
> > > About The Robert Packard Center for ALS Research at Johns Hopkins
> > > www.alscenter. org
> > >
> > >
> > > Located in Baltimore, the Robert Packard Center for ALS Research at
> > > Johns Hopkins is a worldwide collaboration of scientists aimed at
> > > developing therapies and a cure for amyotrophic lateral sclerosis (ALS),
> > > also known as Lou Gehrig's disease.
> > >
> > >
> > > The Center is the only institution of its kind dedicated solely to the
> > > disease. Its research is meant to translate rapidly from the lab bench
> > > to the clinic, largely by eliminating time spent waiting for grants and
> > >
> > > lowering institutional barriers to sharing scientific results.
> > >
> > > Scientists and clinician members of the Packard Center have moved drugs
> > > reliably and rapidly from preclinical experiments to human trials.
> > > Direct or indirect links to international biotech or pharmaceutical
> > >
> > > companies bring the infrastructure and experience needed to make
> > > promising drugs into therapies.
> > >
> > > Packard scientists are the first to propose and test a combination
> > > approach to drug therapy, a tactic that has worked for AIDS, cancer and
> > >
> > > other diseases.
> > >
> > > ALS is a progressive, disabling neuromuscular disease that causes
> > > complete paralysis and loss of function - including the ability to eat,
> > > speak and breathe. ALS progresses quickly and is not curable. Most
> > >
> > > patients die within five years of diagnosis.
> > >
> > > ____________ _________ _________ _________ __
> > > Rebecca Berger
> > > Research Program Coordinator
> > > Robert Packard Center for ALS Research at Johns Hopkins
> > > 5801 Smith Avenue | McAuley Suite 110
> > >
> > > Baltimore, MD 21209
> > > 410.735.7678 direct
> > > 410.735.7680 fax
> > > rberger6@jhmi. edu
> > > www.alscenter. org
> > >
> > > www.fiesta5K. org
> > >
> >
>